Discussion on IRC led to the following conclusions:

* Most tools on Mastodon for blocking are designed with "user runs their own instance" in mind

* Many of the most vulnerable elements of society can't afford to run their own instances, like trans people

* Tools for end-users are insuffiicent

* Existing silence vs suspend is woefully inadequate esp for "grey" instances where some users might be okay but not others

* Users are unable to really block domains

I have no good answers. 🤷