Sunless seas minor spoilers, +
You can change how you're addressed in the game, this is not locked by "gender" : you can choose to be called "my lady" at the start then "my lord" at another point (does require visiting a specific location)
there are quite a few non-hetero relationships
there are a few beings that use "they" pronouns, and at least one that use "it" (and can change in the story to "he", too)
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